Engineering Yarrowia lipolytica for efficient γ-linolenic acid production
نویسندگان
چکیده
منابع مشابه
Engineering of Yarrowia lipolytica for production of astaxanthin
Astaxanthin is a red-colored carotenoid, used as food and feed additive. Astaxanthin is mainly produced by chemical synthesis, however, the process is expensive and synthetic astaxanthin is not approved for human consumption. In this study, we engineered the oleaginous yeast Yarrowia lipolytica for de novo production of astaxanthin by fermentation. First, we screened 12 different Y. lipolytica ...
متن کاملEngineering Yarrowia lipolytica for Campesterol Overproduction
Campesterol is an important precursor for many sterol drugs, e.g. progesterone and hydrocortisone. In order to produce campesterol in Yarrowia lipolytica, C-22 desaturase encoding gene ERG5 was disrupted and the heterologous 7-dehydrocholesterol reductase (DHCR7) encoding gene was constitutively expressed. The codon-optimized DHCR7 from Rallus norvegicus, Oryza saliva and Xenapus laevis were ex...
متن کاملEngineering Yarrowia lipolytica for Enhanced Production of Lipid and Citric Acid
Increasing demand for plant oil for food, feed, and fuel production has led to food-fuel competition, higher plant lipid cost, and more need for agricultural land. On the other hand, the growing global production of biodiesel has increased the production of glycerol as a by-product. Efficient utilization of this by-product can reduce biodiesel production costs. We engineered Yarrowia lipolytica...
متن کاملEngineering Yarrowia lipolytica to enhance lipid production from lignocellulosic materials
Background Yarrowia lipolytica is a common biotechnological chassis for the production of lipids, which are the preferred feedstock for the production of fuels and chemicals. To reduce the cost of microbial lipid production, inexpensive carbon sources must be used, such as lignocellulosic hydrolysates. Unfortunately, lignocellulosic materials often contain toxic compounds and a large amount of ...
متن کاملGenetic engineering of Yarrowia lipolytica for enhanced production of trans-10, cis-12 conjugated linoleic acid
BACKGROUND Conjugated linoleic acid (CLA) has been extensively studied for decades because of its health benefits including cancer prevention, anti-atherogenic and anti-obesity effects, and modulation of the immune system. We previously described the production of trans-10, cis-12 CLA in Yarrowia lipolytica by expressing the gene coding for linoleic acid isomerase from Propionibacterium acnes (...
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ژورنال
عنوان ژورنال: Biochemical Engineering Journal
سال: 2017
ISSN: 1369-703X
DOI: 10.1016/j.bej.2016.10.014